Paracetamol is a widely used non-opioid analgesic and antipyretic, primarily indicated for pain and fever management. Paracetamol’s mechanism of action is not precisely understood, but is thought to involve central inhibition of cyclooxygenase (COX) enzymes and production of the metabolite AM404. Paracetamol is metabolised in the liver, with a minor pathway leading to the formation of a toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), which can cause liver damage in overdose.