Health equity in which all people have a fair opportunity to attain optimal health remains elusive despite decades of innovation. Persistent disparities arise from social determinants of health, structural racism, and health system features that encode historical disadvantage. This chapter examines the innovations across three interconnected levels to advance health equity. At the micro-level, community-based interventions such as street medicine initiatives and community health worker programs directly mitigate barriers faced by marginalized populations. Home-based models of care, peer support networks, culturally responsive education, and health literacy initiatives strengthen trust, promote self-efficacy, and reduce disparities in access and outcomes among underserved communities. At the meso-level, organizational redesign seeks to embed equity within system structures. Hub-and-spoke networks expand specialty services to rural areas, while school-based clinics improve pediatric access. Integrating social care, adapting chronic disease management to cultural contexts, and removing race-based clinical algorithms illustrate how institutions can operationalize equity through practice reform and workforce diversity. At the macro-level, structural interventions target policy reform, diversification of the healthcare workforce and leadership, and the development of comprehensive data infrastructures capable of monitoring and addressing inequities. Nevertheless, substantial challenges persist, including uneven access to innovations, fragmentation across systems, and chronic funding instability. Future directions emphasize ecosystemic frameworks coordinating action across levels, leveraging community-based participatory research to ensure interventions remain culturally grounded and sustainable. Advancing health equity requires deliberate design as the central aim of innovation.