This chapter advances a manifesto for reclaiming Africa in the twenty-first century by re-centering sovereignty, dignity, and epistemic autonomy as the foundation of the continent’s renewal. It argues that political independence, while symbolically significant, remains incomplete without a deeper decolonial transformation that addresses the psychological, cultural, and economic legacies of colonialism and neo-colonialism. Drawing from the works of Achille Mbembe, Kwame Nkrumah, Walter Rodney, Frantz Fanon, Ngũgĩ wa Thiong’o, Ali Mazrui, and other critical voices, the chapter demonstrates that underdevelopment is not a natural condition but a historically imposed structure of extraction, dependency, and alienation. The chapter provides both conceptual summaries of these intellectual contributions and concrete policy recommendations, including rejecting colonial “balance sheet” logics of aid and dependency, investing in indigenous technologies and African-led innovation, restructuring curricula to reflect African philosophies, and reframing Africa’s global engagement to resist new forms of dependency while offering plural and humane alternatives to global governance. Ultimately, reclaiming Africa requires more than dismantling colonial structures of domination—it calls for a visionary, future-oriented project of renewal that transforms exploitation into creativity, alienation into confidence, and dependency into sovereignty.