Background: Breast cancer remains a global health challenge, and early detection strategies like Breast Self-Examination (BSE) can significantly improve outcomes. Despite the high incidence rates, awareness about Breast Self-Examination (BSE) remains low in developing countries. BSE is a simple, cost-effective method to detect early changes in breast tissue. This study aimed to assess the impact of a structured educational intervention using a PowerPoint presentation on improving BSE knowledge among engineering students. Methods: A quasi-experimental design using one group pre-test and post-test was used. The study included 100 female engineering young girls’ students aged 18–26 years, selected through convenience sampling. Participants attended a well-structured BSE training session, after which their knowledge levels were reassessed. Fisher's exact test and paired t-tests were applied in the statistical analysis to assess changes in knowledge scores. Results: Initial assessments revealed insufficient knowledge (mean pre-test score: 9.9 ± 3.2). Post-training, knowledge scores improved significantly (mean post-test score: 20.6 ± 2.8; p < 0.001), demonstrating the training’s effectiveness. Conclusion: Structured training sessions using PowerPoint presentations effectively enhance young girls’ knowledge about BSE. This simple and economical approach can serve as a valuable tool in promoting breast health awareness. Further research incorporating control groups and practice assessments is recommended to evaluate the long-term impact.