Disaster Risk Management (DRM) aims to reduce the impact of catastrophic events through strategies based on territorial data. This study explores the innovative potential of Digital Twin (DT) technology in DRM, a tool that can support real-time decision-making through scenario simulations. Special focus is given to the concept of the Regional Digital Twin (RDT), designed for risk planning and management at the regional level. The adopted methodology is structured into four main phases: building an integrated knowledge system, defining multi-risk scenarios, identifying territorial hotspots, and developing risk management plans. The case study examines the interaction between the RDT and the Regional Civil Protection Plan of Abruzzo, highlighting how the integration of environmental-landscape and socio-settlement data enables modelling of complex scenarios and identification of significant territorial criticalities. Thanks to digital tools like DT, it is possible to generate predictive simulations that can be updated in real time, which are essential to improving prevention and emergency management activities. Future developments will focus on defining operational strategies for risk prevention and mitigation at the regional scale to enhance territorial resilience.