While micro-osteoperforations (MOPs) clearly can increase the rate of tooth movement, if not planned and incorporated thoughtfully into the treatment plan, it may not necessarily decrease the total duration of treatment. In this chapter, we review the concept of target teeth and anchor teeth, supporting the notion that enhancing the biological response around all the teeth, simultaneously without proper planning, is most likely unnecessary and even counterproductive. Therefore, here we discuss how to properly incorporate the catabolic effects of MOPs in each stage of treatment with very specific goals, namely to accelerate the movement of target teeth, facilitate the desired type of tooth movement, develop biological anchorage, or simply decrease the possibility of root resorption by reducing the bone density. Clinical examples for all these situations are discussed in detail.