This chapter analyzes AIDS/HIV activism in Iceland as a multifaceted assemblage of activists, seropositive individuals, public health institutions, and material tools such as condoms and brochures. Beyond prevention, it explores how AIDS/HIV activism challenges stigma, reclaims narrative agency, and generates “desubjugated knowledge”—activist-led insights countering dominant medical discourses. These components come together to form a transformative force that reshapes how AIDS/HIV is experienced and governed. By emphasizing embodiment, materiality, and queer subjectivities, the chapter positions activism not as a mere subset of public health but as a dynamic framework for knowledge production, resistance, and social justice.