This chapter explores the evolving role of the European Union (EU) at the intersection of health and security in the wake of the COVID-19 pandemic. It analyses how the health crisis was followed by deepened integration and a new geopolitical and security-oriented discursive shift, leading to the emergence of the so-called European Health Union, a new Global Health Strategy and recent initiatives to combat hybrid threats, such as health disinformation and cyberattacks on hospitals. The chapter draws on both integration theory and securitisation to gain a deeper understanding of the EU’s increased involvement in health governance. The findings highlight the geopolitical dynamics of this development, including the EU’s concern for strategic autonomy when it comes to pharmaceuticals as well as the use of the Team Europe model and the Global Gateway to strengthen strategic partnerships with the Global South. The chapter concludes by reflecting on the balance between EU’s strategic interests and its commitment to global development and equity in a turbulent world with widening financing gaps and soaring humanitarian needs.