The influence of abiotic environmental conditions and global climate change on non-native species is examined. The significance of multidecadal, interannual, and seasonal variability in abiotic factors for invasive ctenophore population dynamics is analyzed. This is essential for comprehending the role of the abiotic component in ecosystem health and for evaluating the anticipated effects of climate change. The ranges of key environmental parameters—SST, SSS, and Chl concentration—that are conducive to the occurrence and reproduction of M. leidyi and B. ovata have been identified. Regions where all three parameters are currently favorable at the same time have been mapped on a global scale and specifically for the Ponto-Caspian Seas using climatological data. Various global warming scenarios were employed to predict future changes in ctenophore habitats. A key finding from these projections is the significant expansion of M. leidyi reproduction zones: northward into the southern Norwegian Sea and westward into the open North Atlantic. Extensive areas along the Arctic coasts of Eurasia may become suitable for M. leidyi establishment and reproduction. Detailed forecasts of habitat changes for M. leidyi and B. ovata in the Black, Azov, and Caspian Seas are also provided.