The safety of slopes in open-pit coal mines holds immense importance for ensuring the safe operation of these mining sites. Drawing on current research trends, this paper provides an in-depth analysis of the factors influencing slope safety, focusing on geological structure, drainage effectiveness, and blasting vibrations. Furthermore, it proposes a range of measures to bolster the stability of open-pit coal mine slopes. These measures encompass enhancing geological exploration efforts, refining mining techniques and internal dumping strategies, improving drainage systems, implementing rigorous slope monitoring and early warning mechanisms, and mitigating the impact on composite slopes. Finally, the paper presents a comprehensive design and management framework aimed at safeguarding the safety of open-pit coal mine slopes.