Addressing reservoir damage caused by retrograde condensation and water blocking effects during condensate gas reservoir development, this study investigates the mechanism and effectiveness of CO₂ injection unblocking technology for enhancing single well productivity. Using a low-permeability condensate gas reservoir as an example, through PVT experiments, physical simulation experiments, and numerical simulation methods, the reservoir damage mechanism was systematically analyzed, CO₂ unblocking process schemes were designed, and field application effects were evaluated. After CO₂ unblocking, permeability recovery rates reached 60.44%～74.38%, with liquid-phase unblocking agents containing dissolved CO₂ showing the best results. The optimal CO₂ injection volume was 500 × 104 m3/cycle with a soaking time of 10 days. Field application resulted in a 45.2% increase in daily gas production and a 38.6% increase in condensate production per well. CO₂ unblocking technology can effectively eliminate condensate gas reservoir damage, significantly improve single well productivity, and achieve effective CO₂ sequestration, providing a new technical approach for efficient condensate gas reservoir development.