Horizontal wells provide a significantly larger drainage area than vertical wells, offering substantial production advantages. However, pronounced reservoir heterogeneity poses significant challenges to effective acid placement. Considering the current development status of the main upper formations in the Ahdeb oilfield, this study systematically analyzes the key technical difficulties in acid stimulation for horizontal wells and proposes a targeted acidizing strategy. The application of coiled tubing hydraulic jet acidizing technology, integrated with a spindle-shaped acid distribution method, enabled precise targeting. An operational design chart was developed to determine the required injection rates and surface pressures for various nozzle configurations (number and diameter), thereby facilitating optimized treatment design. Field application results demonstrated that post-stimulation production rates increased to 3.8–8.4 times the pre-treatment levels, confirming the significant enhancement of horizontal well stimulation achievable with targeted acidizing technology.