This study conducts the flutter analysis of bio-inspired laminated composite panels in supersonic flow. The governing equations of motion for the 2D laminated plate were established using Hamilton’s principle. The first-order piston theory was employed to model the aerodynamic pressures. The equations of motion were solved by utilizing the Galerkin method. The present approach is verified by comparison with the results of previous publications. Comparison of the critical Mach number value of different material configurations to determine the effectiveness of the bio-inspired laminated composite.