Scour terrain represents an important issue in wave-piles-seabed interactions. While several studies have examined scour effects on wave-induced seabed liquefaction around vertical piles, recognized as key structural failure mechanism. To date, the implications for inclined piles remain inadequately characterized. This knowledge gap persists particularly because asymmetric scour configurations may substantially compromise foundation stability through uneven hydrodynamic re-distribution. This study establishes a validated numerical model integrating wave dynamics and seabed response to assess wave-induced dynamic response and liquefaction, utilizing three-dimensional scour pit topology reconstructed from measured terrain data. The results indicate the following: (1) Scour terrain increases negative wave pressure amplitudes at wave troughs and induces downstream-skewed pressure distributions; (2) The asymmetric scour pattern causes the downstream pore pressure decaying more slowly along depth due to the larger scour area downstream; (3) Comparing to the flat seabed cases, maximum liquefaction depth in scoured beds could increase by 46%; (4) The liquefied depth around inclined piles is usually larger than that around the vertical in both the flat and scoured seabed. And the effects amplify with pile inclination due to varying hydrodynamic characteristics; (5) Parameterized study shows that the low-permeability seabed is more sensitive to the scour boundary, thereby amplifying the scour effects. The influence of saturation is less noticeable.