Scholarlink

HMPAO is a lipophilic chelator of Tc-99mO4. Following i.v. injection, Tc-99m-HMPAO is cleared from blood rapidly and becomes widely distributed in the body, freely entering cells on account of its lipophilicity. It is therefore an example of a chemical microsphere and was developed to image the distribution of cerebral blood flow. Later, its properties as a lipophilic chelator were exploited to label autologous leucocytes for white cell scanning. Tc-99m-HMPAO is used to diagnose cerebral atrophy in the dementias and to identify epileptogenic foci in epilepsy but has been largely replaced for brain imaging by FDG PET/CT.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Tc-99m-Hexamethylpropylamine Oxime (HMPAO) (MW 385 Da)

  • 章节

  • 发表日期：

    2026年

查看全文
  • Adrien Michael Peters,
  • Manuela Vadrucci

摘要

HMPAO is a lipophilic chelator of Tc-99mO4. Following i.v. injection, Tc-99m-HMPAO is cleared from blood rapidly and becomes widely distributed in the body, freely entering cells on account of its lipophilicity. It is therefore an example of a chemical microsphere and was developed to image the distribution of cerebral blood flow. Later, its properties as a lipophilic chelator were exploited to label autologous leucocytes for white cell scanning. Tc-99m-HMPAO is used to diagnose cerebral atrophy in the dementias and to identify epileptogenic foci in epilepsy but has been largely replaced for brain imaging by FDG PET/CT.