This chapter presents the rationale, structure, and clinical implementation of rehabilitative inpatient CBT-E for adolescents with severe eating disorders. While outpatient treatment remains the preferred setting due to its integration with everyday life, a subset of patients requires more intensive intervention due to illness severity, safety concerns, or failure to respond to outpatient care. The treatment preserves the core features of outpatient CBT-E while adapting the format for a more intensive setting. Key innovations include a personalized, formulation-based approach; a collaborative, non-coercive therapeutic style; and structural elements designed to address in a personalized way the eating disorder psychopathology and its maintenance mechanisms. Admission criteria, treatment phases, team composition, and environmental considerations are thoroughly described. A multidisciplinary CBT-E team delivers the treatment in an open, home-like setting to minimize institutionalization and maximize exposure to real-life triggers in a supportive environment. The programme includes modular interventions tailored to each patient’s maintaining mechanisms, with both focused and broad forms of CBT-E available. Throughout the programme, emphasis is placed on fostering patient autonomy, enhancing motivation, managing daily challenges, and developing individualized relapse-prevention skills. The chapter concludes with a discussion of common implementation challenges, including waning motivation, peer influence, and medical instability, as well as strategies for managing them within the CBT-E framework.