This chapter presents the rationale, structure, and implementation of day-hospital CBT-E for adolescents with eating disorders. Positioned as the third level of care intensity within the multistep CBT-E model, this approach is designed for patients with moderate to high medical or psychological risk who require close supervision and consistent meal support but do not necessitate full inpatient care. Day-hospital CBT-E maintains the core components of standard CBT-E while integrating additional strategies, such as assisted meals, individual and group sessions, regular medical monitoring, and structured weekend planning, to address persistent challenges, including undereating, binge-purge behaviours, and difficulties achieving weight regain. Treatment is conducted in a psychologically supportive setting by a multidisciplinary team trained in CBT-E, including psychologists, dietitians, and physicians. Core features of the program include real-time self-monitoring, collaborative weighing, dietary support, and active parental involvement to reinforce eating behaviour changes at home. As patients progress, they are gradually transitioned to unassisted and socially integrated meals, supporting long-term recovery and autonomy. Day-hospital CBT-E provides a cost-effective, lower-stigma alternative to inpatient care, ensuring continuity of treatment while reducing relapse risk by facilitating behavioural change in the patient’s everyday environment.