Modeling cognitive, emotional, and motor impairments using animal models is an essential approach to elucidate the pathogenesis and develop effective therapeutic interventions in neurodegenerative diseases. Cognitive impairments, including memory deficits, attentional dysfunctions, and impaired executive functions, are prevalent features of major neurodegeneration-associated diseases. Motor and emotional disorders are also reported. To study these alterations, vertebrate animal models, mainly rodents, are used to reproduce as much as feasible the pathological phenomena in human disorders. The assessment of cognitive, motor and emotional disorders in animal models is based on the use of well-established behavioral tests. However, research with rodents often poses ethical, financial and technical challenges. Therefore, the use of alternative models is a promising solution to study neurodegenerative diseases. In particular, the zebrafish is of increasing importance. This perspective is reinforced by the fact that the behavioral register of these animals is increasingly clarified.