Religion and spirituality play a profound role in shaping the health and quality of life (QoL) of Black same-gender-loving (SGL) men. Across the African diaspora, religious teachings and institutions are deeply embedded in early socialization, often generating enduring tensions between faith and sexuality. For U.S. Black SGL men, this tension is especially complex because the Black Church has long functioned as both a pillar of cultural affirmation and a site of exclusion through heteronormative doctrine, especially in the South. Yet, the same institution has also served as a catalyst for health advocacy, social cohesion, and community resilience. Recognizing the World Health Organization’s framing of spiritual well-being as a core component of holistic health, this chapter situates the role of religion and spirituality within a Life Course framework that emphasizes how early religious socialization, developmental transitions, and intergenerational ties shape Black SGL men’s health and well-being over time. This chapter underscores how faith-based experiences, whether affirming or stigmatizing, are embedded within networks of family, peers, and community, which influence health trajectories across the lifespan. Drawing on both established literature and firsthand narratives from participants in the Snap Out Stigma (SOS) Photovoice Project in Memphis, Tennessee, this chapter illustrates how participants’ reflections exemplify Life Course dynamics. Their stories of trauma, resilience, and spiritual evolution mirror broader patterns documented in public health and sociological research, while extending theoretical understandings of how religion functions as both a site of harm and a reservoir of healing. By weaving the SOS narratives with empirical and conceptual insights, the chapter demonstrates how faith and spirituality intersect with identity, community belonging, and health behavior across time. It concludes by identifying opportunities for faith-engaged interventions that center affirming spiritual frameworks and reframe faith as a psychological, cultural, and communal resource for restoration and healing beyond theology.