The ability to monitor and manipulate cell signaling events is critical for understanding cellular functions in health and pathology. Our lab has been working to expand on the tools available to noninvasively monitor and manipulate cellular functions both in cell models and model organisms. To address the need for more advanced methods to study and manipulate cell signaling events, our lab developed Bioluminescent Kinase Sensors (BlinKS) that increase in brightness in response to specific kinases and pairing them with optogenetic transcription systems to create kinase dependent Genetic Circuits, BlinKS-GC. The use of bioluminescent-based sensors paired with optogenetic actuators to create cell signaling-based integrators offers high flexibility in that manipulations are dependent on a specific kinase activity and the presence of luciferin, where brightness can be tuned based on luciferin concentration and the on/off kinetics of the sensor can be tuned by engineering. BlinKS can be used for noninvasive reporting of cell signaling and dynamic control over signaling events in genetically defined cell types for basic research relevant to a variety of different diseases and biological processes. The use of these sensors can not only enhance our understanding of cell signaling processes, but also open new avenues for therapeutic intervention either through mechanistic understanding of cellular processes or by adapting this system to correct aberrant cell signaling events.