Efficient and sustainable water resource management is becoming increasingly important, particularly in subtropical climates. Therefore, a holistic framework that integrate empirical field methodologies and GIS analysis can offer a potential approach for creating effective water resource planning. The Integrated Semi-Empirical and Spatial Water Resources Framework (ISES-WRF), which integrates semi-empirical estimating techniques with spatial analysis using Geographic Information Systems for sustainable watershed management, is discussed in this chapter. To accurately assess water resources and develop a map for a water resource action plan, the chapter highlights the importance of integrating semi-empirical techniques with spatial datasets. It covers fundamental concepts such as water balance techniques, thematic mapping, and the spatial overlay of hydrological indicators, while emphasizing the problems of data variability of existing methodologies. A comprehensive case study is presented from the Aleikera micro-watershed of Odisha, India, where the ISES-WRF technique was employed to develop an integrated water resource action plan. Calculation of water balance parameters, generation of thematic maps, and spatial overlay methods were used to identify suitable regions for water conservation structures. The chapter concludes by discussing the possibility of expanding the ISES-WRF framework to other identical hydrological regions to improve sustainable water resource planning under changing environmental conditions.