This concluding chapter examines whether the academic profession is best understood through national, global, or regional perspectives. Drawing on evidence from the APIKS survey and earlier comparative projects, it revisits the evolution of comparative research on academic work and evaluates the analytical value of the regional lens. The chapter reviews different ways of conceptualizing regions, including geographical, cultural, and policy-based groupings, and highlights key conceptual and methodological challenges. Synthesizing findings from the volume, it shows that regional patterns can be identified in some domains of academic work, but that their strength and coherence vary and are often mediated by national contexts. The chapter therefore argues for a multi-layered analytical framework integrating national, regional, and global dimensions.