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In this work, three hydrogels of alginic acid crosslinked with three different amines were synthetized by means of coupling reaction. The gels formation was confirmed by means of FT-IR analysis and their ability to swell was evaluated measuring their capacity of water absorption. The rheological properties were also measured and influenced by the length of hydrocarbon chain of amines used as crosslinker in the gels synthesis (1,4-bis(3-aminopropyl) piperazine, 1,4-diaminobutane and spermidine). In addition, the morphologic and average size of porous was studied by means of scanning electron microscopy and influenced by the type of used amine in the synthesis process. Finally, hydrogels were evaluated by biocompatible and cytotoxicity assays on chick embryo chorioallantoic membrane, where hydrogel with spermidine exhibited a remarkable 100% embryonic viability.

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Hydrogels Synthesis of Alginic Acid as Potential Tissue Regeneration Scaffolds

  • 章节

  • 发表日期：

    2026年

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  • Juan Salazar-García,
  • Mónica Corea,
  • Gabriela Martínez-Mejía,
  • Lazaro Ruiz-Virgen,
  • Rogelio Jiménez-Juárez,
  • Rubén Caro-Briones,
  • Roberto Carlos Lazzarini-Lechuga,
  • Ana Lorena González-Vadillo,
  • José Manuel del Río

摘要

In this work, three hydrogels of alginic acid crosslinked with three different amines were synthetized by means of coupling reaction. The gels formation was confirmed by means of FT-IR analysis and their ability to swell was evaluated measuring their capacity of water absorption. The rheological properties were also measured and influenced by the length of hydrocarbon chain of amines used as crosslinker in the gels synthesis (1,4-bis(3-aminopropyl) piperazine, 1,4-diaminobutane and spermidine). In addition, the morphologic and average size of porous was studied by means of scanning electron microscopy and influenced by the type of used amine in the synthesis process. Finally, hydrogels were evaluated by biocompatible and cytotoxicity assays on chick embryo chorioallantoic membrane, where hydrogel with spermidine exhibited a remarkable 100% embryonic viability.