Efficient microbial bioprocess development is a key enabler for the scalable manufacturing of bio-based products. While traditional small-scale cultivation formats such as microplates and shake flasks offer high experimental throughput, they provide only limited process control and monitoring. To harness their throughput without compromising data quality, advanced solutions for online monitoring, automation, and liquid handling have emerged. These allow real-time analytics, automated sampling, feeding, and pH control—even at microliter scale. Microbioreactors exemplify this evolution: they enable the parallel cultivation of dozens of microbial cultures while integrating sensors for key bioprocess parameters. When combined with microfluidics or robotic liquid-handling systems, they achieve a level of process insight and control similar to stirred-tank bioreactors. This chapter provides a comprehensive overview of current technologies in parallelized small-scale bioprocessing—spanning microbioreactor systems, shake flask-compatible tools, and setups for fed-batch or continuous cultivation. The large datasets generated by these systems can be efficiently leveraged through data science methods, enabling algorithm-guided and data-driven experimentation. Together, these advances mark a shift toward more automated, reproducible, and scalable microbial bioprocess development.