The article contains the results of an analysis of the design options for the vibration-isolated foundation of a high-speed turbogenerator set operating as part of an atomic energy facility in the conditions of increased seismic activity. A fundamental model of the turbine building, incorporating a vibration-isolated foundation for the turbogenerator, was established at the outset of the research. This primary model then served as the basis for generating multiple alternative versions, which embodied distinct design solutions for the vibration isolation system. To implement the abovementioned models, a finite element model was created in the simulation environment “MCS.Nastran/Patran”. The main design characteristics used for the comparative analysis of alternative constructive solutions were: peak seismic accelerations; zero period acceleration; highest deformations of isolating elements. At the final stage, computational experiments and a qualitative analysis of the results were carried out. Based on the results of the procedure, it was concluded that the design solution is preferable, involving the use of dampers together with spring isolators with increased horizontal stiffness under the condensers, and a combination of spring and spring-damper isolators in the supports of the turbogenerator set foundation.