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Ion-Sensitive Field-Effect Transistors (ISFETs) have emerged as a crucial technology in biomedical engineering, particularly for Lab-on-Chip (LoC) applications. These devices measure ionic concentrations in solutions using array-based configurations. To achieve accurate readings, read-out circuits must efficiently handle dense arrays, variable measurement times, and high sampling rates. The most widely used analog front-end for ISFET arrays is the constant voltage constant current (CVCC) readout technique, ensuring reliable and sensitive ion concentration measurements. This work presents a 4-channel CVCC read-out circuit for multi-ionic analysis, focusing on sodium, potassium, ammonium and pH detection. The system combines analog and digital sections and enables real-time, multiplexed analysis of multiple analytes within a single platform.

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Development of ISFET Array Architectures for Real-Time Multiparametric Analysis

  • 会议论文

  • 发表日期：

    2026年

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  • Giuseppe Coviello,
  • Antonello Florio,
  • Giuseppe Brunetti,
  • Christian Lazzari,
  • Daniele Triggiani,
  • Caterina Ciminelli

摘要

Ion-Sensitive Field-Effect Transistors (ISFETs) have emerged as a crucial technology in biomedical engineering, particularly for Lab-on-Chip (LoC) applications. These devices measure ionic concentrations in solutions using array-based configurations. To achieve accurate readings, read-out circuits must efficiently handle dense arrays, variable measurement times, and high sampling rates. The most widely used analog front-end for ISFET arrays is the constant voltage constant current (CVCC) readout technique, ensuring reliable and sensitive ion concentration measurements. This work presents a 4-channel CVCC read-out circuit for multi-ionic analysis, focusing on sodium, potassium, ammonium and pH detection. The system combines analog and digital sections and enables real-time, multiplexed analysis of multiple analytes within a single platform.