Cancer and health-related community outreach and education efforts continually rely on health communications to reach and inform important target audiences. Community-based presentations, prevention messaging, and dissemination of cancer screening information to increase knowledge and preventative behaviors among Indigenous communities are critically important because cancer is one of the leading drivers of morbidity and mortality. As an exemplar, media-based health communication efforts led by community partners in a collaborative framework with a federally (USA) designated cancer center’s Department of Indigenous Cancer Health, Community Outreach and Engagement program, and Health Communications Resource are shared. Communications were designed for Indigenous media networks and community-based film companies. Topics included health, cancer prevention, and cancer screening. The health communication model for dissemination of mass media creations involved film and media screenings, panel discussions, and influencer platforms integration; communications were preserved in the cancer center’s Indigenous outreach and engagement digital repository. Evaluation efforts to improve the quality of health communication processes revealed the importance of coproducing films under the guidance of community advisory boards, and conducting surveys of knowledge, attitudes, and prevention and screening behaviors. These experiences highlight how organizations responsible for cancer care can create engaging stories and health messaging for Indigenous communities.