Transcatheter arterial microembolization (TAME) has emerged over the past decade as a novel therapy for chronic musculoskeletal pain, challenging long-standing assumptions about the dangers of interrupting arterial blood flow. Traditionally associated with life-saving interventions for hemorrhage or tumor management, embolization was never considered suitable for joints, tendons, or ligaments due to concerns regarding ischemia or tissue damage. However, contemporary vascular biology has clarified the pathological role of aberrant hypervascularization in conditions such as osteoarthritis, tendinopathy, adhesive capsulitis, and rheumatoid arthritis. These immature vessels not only sustain chronic inflammation but also serve as conduits for nociceptive nerve in growth, amplifying pain. Temporary embolic agents, such as imipenem/cilastatin, allow safe, transient occlusion that collapses pathological vessels while preserving normal perfusion. Building on this principle, a simplified, ultrasound-guided approach—termed Dochu—has been developed to make embolization accessible outside fluoroscopy-equipped angiography suites. By injecting temporary embolic material directly into superficial arteries near the target lesion, clinicians can achieve therapeutic outcomes comparable to catheter-based embolization. Flow modulation using simple tools such as blood pressure cuffs further enhances targeting through collateral pathways. Clinical studies across multiple anatomical regions demonstrate significant reductions in pain and improvements in function, with procedures completed in minutes, minimal complications, and the ability to repeat treatment when needed. Dochu represents a paradigm shift: a minimally invasive, scalable technique that democratizes embolization and expands its use to outpatient settings. This book introduces the scientific foundations, technical principles, clinical indications, and procedural guidance necessary for safe and effective adoption of this transformative approach.

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Introduction

  • Yuji Okuno,
  • Ralph Rogers,
  • Alexander Loizides

摘要

Transcatheter arterial microembolization (TAME) has emerged over the past decade as a novel therapy for chronic musculoskeletal pain, challenging long-standing assumptions about the dangers of interrupting arterial blood flow. Traditionally associated with life-saving interventions for hemorrhage or tumor management, embolization was never considered suitable for joints, tendons, or ligaments due to concerns regarding ischemia or tissue damage. However, contemporary vascular biology has clarified the pathological role of aberrant hypervascularization in conditions such as osteoarthritis, tendinopathy, adhesive capsulitis, and rheumatoid arthritis. These immature vessels not only sustain chronic inflammation but also serve as conduits for nociceptive nerve in growth, amplifying pain. Temporary embolic agents, such as imipenem/cilastatin, allow safe, transient occlusion that collapses pathological vessels while preserving normal perfusion. Building on this principle, a simplified, ultrasound-guided approach—termed Dochu—has been developed to make embolization accessible outside fluoroscopy-equipped angiography suites. By injecting temporary embolic material directly into superficial arteries near the target lesion, clinicians can achieve therapeutic outcomes comparable to catheter-based embolization. Flow modulation using simple tools such as blood pressure cuffs further enhances targeting through collateral pathways. Clinical studies across multiple anatomical regions demonstrate significant reductions in pain and improvements in function, with procedures completed in minutes, minimal complications, and the ability to repeat treatment when needed. Dochu represents a paradigm shift: a minimally invasive, scalable technique that democratizes embolization and expands its use to outpatient settings. This book introduces the scientific foundations, technical principles, clinical indications, and procedural guidance necessary for safe and effective adoption of this transformative approach.