Lung Cancer is one of the world’s deadliest cancers and has 1.8 million new cases and 1.6 million deaths annually. Survival rates after five years are very low, ranging from 4% to 17%, due to the timing of detecting cancer and, to some extent variation in healthcare. Conventional treatments are chemotherapy, radiation therapy, and surgery. There are various drugs available in the market to treat Lung cancer like Erlotinib, Afatinib, Osimertinib, Gefitinib, Crizotinib, Alectinib, Lorlatinib, Brigatinib, Crizotinib, Entrectinib, etc. However, they carry vital side effects and toxicity concerns. To combat such issues, herbal products have been used for their synergetic efficacy. Nano biomaterial-based herbal formulations have been proven to exert improved anticancer potential against lung cancer by inhibiting growth, blocking the blood flow towards growing cancerous tissues, and activating programmed cell death. More strikingly, these nanomaterials have properties that are nontoxic, bio-compatible, and degradable, which makes them significantly less harmful than traditional synthetic drugs. This chapter comprehensively describes the various herbs discussed in literature against Lung cancer, insight into available herbal nanomaterials, and their mechanism of action on Lung cancer specifically.