The overall burden of parasitic diseases in developing countries with poor resource continues to surge despite advances in global collective interventions based on outcomes from cutting-edge technologies. Africa has high rates of parasitic infections from helminths (worms) and protozoa, which cause significant health issues, particularly in children. Common helminths in Africa include soil-transmitted helminths like Ascaris and hookworms and schistosomes. Prominent members of the protozoa family include but not limited to Entamoeba histolytica, Giardia duodenalis, and Cryptosporidium. These parasites are linked to problems like stunted growth, anemia, renal failure, bladder cancer, low birth weight, fetal loss, advanced liver fibrosis, portal hypertension, variceal bleeding, ascites, advanced malnutrition, depression, divorce, social stigma, motor dysfunction/paraparesis, pulmonary inflammation, hypertension, decreased productivity, and many more complications. The ultimate effectiveness of an eradication campaign depends not only on favorable biological elements but also on society acceptance of the intervention and political will to implement it. Funders and researchers should work in tandem to clamp down the surge of these parasites-associated infections especially in resource-limited settings.