This chapter of the book explores the application of blockchain technology in supply chain optimization through detailed case studies. As the complexity and fragmentation of food supply chains increase, so do the associated challenges such as fraud, inefficiencies, and sustainability issues. Blockchain technology presents a transformative solution with its decentralized, transparent, and immutable characteristics, offering improved traceability and efficiency in supply chain management. The first case study examines Walmart’s collaboration with IBM to integrate the IBM Food Trust platform, enhancing food safety and traceability across its global supply chain. The second case focuses on GrainCorp’s adoption of the AgriDigital platform to address logistical and financial challenges within the Australian grain supply chain. The third case study highlights Starbucks’ use of Microsoft’s Azure Blockchain Service to enhance the sustainability and transparency of its global coffee supply chain. Each case study demonstrates the specific benefits of blockchain implementation, such as increased transparency, reduced waste, and improved supplier relationships, thereby providing insights into the broader potential of blockchain technology in optimizing supply chains across various sectors.