This chapter explores the case study (CS) method as an effective pedagogical approach to enhance student engagement, critical thinking, and comprehension in undergraduate plant biology studies. In order to connect theoretical knowledge to practical applications, CS allows students to analyze real-life problems and encourage critical thinking of plant biology concepts. Moreover, CS helps students develop problem-solving skills and collaborative learning. Instructors can utilize various plant biology case studies. By incorporating the CS method into plant biology, educators can enhance student learning and prepare students for the future.