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In this chapter, an integrative fifth-order biological and mental network model is introduced, to demonstrate epigenetics effects in Post-Traumatic Stress Disorder (PTSD), using an adaptive network modeling approach based on temporal-casual networks. The network model assesses DNA methylation dysregulation, on glucocorticoid receptors, and side effects of glucocorticoid receptor hyperreactivity to glucocorticoids in fear processing of individuals with post-traumatic stress disorder. Furthermore, a form of therapy is explored on differently methylated genes. Genes NR3C1 and FKBP5, and their expression were chosen for the demonstration, furthermore, administering MDMA was chosen as a form of therapy. Several simulations were run to analyze and illustrate behavior of the network model. Behaviors for both genes and their expression were tested together and individually.

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Multi-Order Adaptive Network Modeling for Pathways of DNA Methylation and Their Effects on Memory Regulation Leading to Flashbacks and PTSD

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  • 发表日期：

    2026年

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  • Iva Gunjača,
  • Natalie Samhan,
  • Jan Treur

摘要

In this chapter, an integrative fifth-order biological and mental network model is introduced, to demonstrate epigenetics effects in Post-Traumatic Stress Disorder (PTSD), using an adaptive network modeling approach based on temporal-casual networks. The network model assesses DNA methylation dysregulation, on glucocorticoid receptors, and side effects of glucocorticoid receptor hyperreactivity to glucocorticoids in fear processing of individuals with post-traumatic stress disorder. Furthermore, a form of therapy is explored on differently methylated genes. Genes NR3C1 and FKBP5, and their expression were chosen for the demonstration, furthermore, administering MDMA was chosen as a form of therapy. Several simulations were run to analyze and illustrate behavior of the network model. Behaviors for both genes and their expression were tested together and individually.