Immersion learning is an active experience-driven educational methodology that promotes meaning-driven learning through a process of cognitive, emotional, and participative interaction that is much richer and fuller than traditional educational equivalences. Immersion in science education involves communities of learners participating in the process of coming to know the living world, whose understanding is necessary for the well-being of the global community. In effect, scientific immersion consists of learners meaningfully interacting with the living world while experiencing the key elements of the scientific process provided by specific phenomena. Through scientific immersion, learners also subjectively experience the cognitive and emotional significances of scientific knowledge and its cultural roots that transform culture at the frontiers of human knowledge. As such, scientific immersion should occur with phenomena that are of personal, cultural, and scientific significance for learners. Immersion learning emphasizes experience-driven science education, and recognizes the primary role that scientific practice plays in the process of coming to know the living world. Experimentation is the key element that distinguishes scientific practice from other experiential activities. Immersion learning accesses the cognitively demanding and deep learning of valid yet contradictory logic-based interpretation, experimentation, and conceptualization that leads to propositional knowledge and mental models. Learners appropriate these logically related sets of experiment-derived knowledge and models in uniquely personal ways and emotional contexts and encode them in a particular art-based format that are the cognitive structures that ultimately constrain teachers’ and learners’ attempts to link new knowledge with that associated with the art object and its corresponding context. This chapter explores immersion learning in science teaching and learning.