Cranioplasty implants are applied for medical cure of human cranial diseases, e.g. skull cancer, malformation or cranial trauma after accident. Particular crucial for long term curing is the acceptance of the implant by the human body and its long-term integrity, which is generally achieved using biocompatible materials such as grade 5 titanium. As each medical implant is an individual product, flexible and adaptive manufacturing processes are in need to allow for an economic and automated fabrication. In the past, metallic implants have been fabricated directly by subtractive or additive processes. In an experimental approach, these implants were fabricated by forming of sheet metal plates in 3D-printed tools from polymer. In the light of this feasibility study, a rapid tooling process from cheap, recyclable materials, which can be applicated to directly manufacture molds from spatial scan data is demonstrated. Based on sheet metal forming, the presented process minimizes material effort of highly expensive titanium alloys while at the same time allows for the economical and rapid fabrication of individual single plate implant parts.