Innovation Systems are dynamic ecosystems that integrate individuals, organizations, policies and processes to drive innovation, economic growth and employment. This work explores collaborative upskilling and customized connectivity as key enablers of innovation. The concept of Focus Parcours is introduced to facilitate specialized, adaptable learning pathways tailored to regional, industry-specific or thematic needs. These pathways strengthen Local, Regional and National Innovation Systems by enhancing targeted education and skills development. Connectivity emerges as a cornerstone of innovation ecosystems, blending physical infrastructures with digital layers to foster seamless integration. Human-centricity remains at the core of this approach, with an envisioned digital overlay connecting the proposed innovation infrastructure and enabling cross-border knowledge exchange within a Global Innovation System. This paper highlights customizable elements and the flexibility of the proposed strategy, enabling a holistic approach to infrastructure usage, tailored upskilling efforts and connectivity solutions to specific goals—whether enhancing regional innovation capacities, fostering industry-specific collaboration or addressing global challenges. Aligning education, infrastructure and collaboration fosters a transnational innovation mindset and sustainable growth.