Membrane trafficking is crucial for various aspects of plant growth, development, and responses to environmental stimuli. The trans-Golgi network (TGN) in plants serves as a central sorting station for membrane trafficking and operates at the intersection of the biosynthetic and endocytic pathways for both plasma membrane/extracellular molecules and vacuolar proteins. Although the molecular machinery that controls membrane trafficking is evolutionarily conserved, how plant TGNs perform their multiple sorting operations still remains poorly understood. Multitasking of plant TGNs manifests as a partition of the molecular machinery within a single organelle. This chapter presents the current state of knowledge on plant TGNs, explores emerging concepts in the field, and highlights key questions and challenges for future research.