The United Nations Sustainable Development Goals (SDGs) largely conceptualise sustainability and development according to modernist capitalist logics derived from the Global North. As Indigenous communities and members of United Nations special groups have pointed out (United Nations, Department of Economic and Social Affairs, Indigenous Peoples, Indigenous peoples and the 2030 agenda, n.d.), some SDGs may involve the appropriation of First Nations lands in order to carry out sustainable development goals. The absence of a specific SDG related to First Nations communities at a time of rapid language and knowledge loss (epistemicide) also creates concerns for the translatability of the SDGs for meaningful development and sovereign cultures. Communication is a crucial component to many of the principles outlined in the United Nations Declaration on the Rights of Indigenous Peoples (such as Articles 2 and 3 on self-determination and autonomy) and the capacity for First Nations communities to have input into the implementation of SDGs (see Randell-Moon, SDG18 communication for all, volume 2: Regional perspectives and special cases, Palgrave, 2024). Sovereign communication is central to the implementation of development and sustainability initiatives that benefit and prioritise First Nations’ needs. The emergence of artificial intelligence (AI) is premised on similar norms to the SDGs, having been predominantly established in data and geopolitical contexts where First Nations involvement is not prioritised and with an assumed orientation towards economic growth (Russ-Smith & Lazarus, The AI (R)evolution: Valuing country, culture and community in a world of algorithms, Monash University Publishing, 2024). There are risks of algorithmic bias and data injustice for First Nations communities as well as significant environmental imposts for AI’s proliferation as a policy tool in sustainability domains. In a context where technological developments occur in the Global North with the requirement for other geopolitical and cultural spaces to catch up, AI already promotes knowledge and development norms (and tech-induced environmental imposts) which further undermine First Nations sustainability efforts. This chapter focuses on the threats of AI to First Nations-led sustainability in relation to sovereignty and self-determination and outlines recommendations for AI ethics to ensure alignment with First Nations-led development goals.