The Italian Seismic Code (ISC) identifies 8 existing masonry typologies recurring throughout the national territory with reference ranges for the main strength and deformability parameters (compressive and shear strength, elastic and shear modulus). However, the mechanical features of existing masonry represent a real challenge, since they are characterized by a wide variety of materials and constructive techniques based on local knowledge and availability. Thus, this classification cannot be exhaustive. The ISC itself suggests that local authorities (i.e., Regions) should promote local studies and consider specificities. This work analyzes the ISC ranges through comparisons with experimental data from in-situ tests (e.g., double flat-jacks, diagonal compression tests, suggested by the ISC itself to characterize mechanical parameters in the professional field), performed in the context of the Marche Region by certified laboratories. Quartile-based analyses are performed to draft regional ranges upon over 400 experimental in-situ tests collected. Comparisons consider all the masonry typologies included in the ISC and a new-one still not included, which is the stone-and-masonry mixed masonry. Results about the compressive strength demonstrate a poor agreement between regional data and the ISC provisions, especially considering the minimum values, as well as for the elastic modulus. Conversely, although far fewer tests have been collected to date, shear parameters seem to highlight a better fit. This work provides practitioners with valuable findings to classify and assess local masonry, supporting structural evaluations and compliance with ISC guidelines. Future efforts should focus on expanding and diversifying the types of tests and masonry analyzed.