Redesigning Piazza dei Cinquecento: Enhancing Safe, Multimodal, and Pedestrian-Friendly Mobility at Roma Termini The redevelopment of Piazza dei Cinquecento and the Roma Termini interchange hub addresses key urban challenges such as sustainable mobility, pedestrian safety, and the quality of public space. Initiated in 2020 and supported by Jubilee 2025 funding, the project reflects a collaborative effort between Roma Capitale and FS Sistemi Urbani, integrating mobility strategies from the city’s Sustainable Urban Mobility Plan (PUMS) with a context-sensitive urban design approach. The planning process unfolded in three phases: an assessment of existing conditions based on multimodal transport data, pedestrian flows, and spatial conflicts; the development of a two-part strategy to reduce private traffic and improve pedestrian navigation through natural wayfinding; and the elaboration of a detailed layout using macro- and micro-simulation tools. A central innovation is the reconfiguration of the bus terminal through macro-islands, replacing traditional linear platforms. This design enhances spatial legibility, simplifies intermodal transfers, and improves overall pedestrian comfort and safety. The fast-tracked implementation has served as a real-world laboratory for stakeholder coordination and adaptive design under time constraints. Although still in progress, the project has already generated observable changes in mobility behaviour, demonstrating its potential as a replicable model for safe, accessible, and integrated urban transport systems.