This chapter explores the psychology of South Asian shame, integrating psychological well-being, neurobiology, clinical presentations, and socio-cultural manifestations. It introduces a psychological well-being framework, adapting Seligman’s PERMAH model to contextualise well-being within South Asian diasporic populations, extending it to include community and collective dimensions. The chapter then examines the neurobiological underpinnings of shame, including neural circuits, stress regulation, and developmental trajectories, highlighting distinctions between shame and guilt and their implications for culturally specific experiences. Clinical presentations are explored, covering somatic symptom disorders, complex PTSD, depression, anxiety, relational and collective dynamics, personality features, and coping mechanisms such as dissociation and substance use. The chapter further investigates the social and cultural masks of shame, including financial behaviours, false consciousness, honour, marriage, and cognitive dissonance, as well as the patriarchal and colonial manipulation of religion in perpetuating shame. Real-life case studies illustrate these dynamics, providing a comprehensive, interdisciplinary approach to understand the multifaceted psychological realities of South Asian diasporas.