Fences are ubiquitous across the world’s landscapes. As a result, fence ecology—the empirical study of interactions between fences, organisms, ecosystems, and societal needs—is gaining more attention among researchers and practitioners. While road ecologists often incorporate fences along roads as tools to reduce wildlife–vehicle collisions, fence ecology views all fences from a broad landscape perspective. Road ecology can benefit from fence ecology by considering wildlife mitigation along transportation corridors in concert with fence networks in the surrounding landscape. Understanding how fences affect animal movements and wildlife–vehicle collisions, impact the efficacy of safe wildlife crossing opportunities, and contribute to the cumulative effects of infrastructure on ecosystems, can improve road planning, design, and mitigation. Here, we explore the intersection of fence ecology with road ecology and advocate for use of a context-sensitive design (CSD; also termed context-sensitive solutions, CSS) approach to merge the principles of these disciplines by using a broad landscape perspective. By integrating fence and road ecology through CSD or CSS, we can design appropriate fence systems and road mitigation measures that benefit human economic needs, social values, and restore, maintain, or improve the function and resiliency of ecosystems.