Roadless areas have recently emerged as timely conservation targets in the context of global environmental change and the biodiversity and climate crisis. They are land units (almost) free from road impacts and associated human disturbance, and, thus, represent functioning and resilient ecosystems, support biodiversity, and provide ecosystem services. Given the current explosion of road development, roadless areas are disappearing at a quick pace before being even inventoried. Road mapping is generally inaccurate, particularly in natural areas and at large spatial scales, and this is a main issue that hinders roadless areas research and conservation, and the take-off of Roadless Ecology in general. Roadless Ecology follows an opposite but complementary approach to Road Ecology and changes the focus from the ecological effects of roads to the ecological effects of their absence. With a few exceptions, roadless areas are not considered in the national and international legislation, and they have been neglected in conservation, transport, and climate policies. A roadlessness and fragmentation minimization policy is urgently needed in all sectors. Roadless lands are perfect candidates for inclusion within the target of protecting 30% of the Earth by 2030. The absence of roads is often accompanied by the absence of most conflicting uses with biodiversity conservation and associated economic cost; therefore, the protection of roadless areas is probably the most cost-effective way to safeguard biodiversity and climate resilience.