According to the classification of International Society for Study of Vascular Anomalies, vascular anomalies are divided into vascular tumors and vascular malformations. Vascular tumors are further divided into benign, locally aggressive (borderline), and malignant; and vascular malformations are subdivided into simple, combined, malformation of major named vessels, and malformation associated with other anomalies. Vascular tumors (mostly hemangiomas) are characterized by endothelial cell proliferation, and vascular malformations are structural vascular abnormalities. These two types of lesions have different clinical behavior and require different diagnostic and therapeutic strategies. Infantile hemangiomas are the most common benign soft tissue tumors of infancy that affect 4–5% of infants, mostly located in head and neck region, with female predomination. The pathophysiologic mechanisms leading to endothelial cells proliferation and involution are not completely understood. Most infantile hemangiomas are small, harmless tumors that should be allowed to involutes without treatment. Generally, treatment is instituted for complications within the infantile hemangiomas itself or impairments caused by the hemangioma. Current treatment options include propranolol, surgery, laser treatment, corticosteroids, and chemotherapy, sole or as a combination.