Islamophobia has increased in the years following the events of September 11, 2001, and has impacted Muslims on a global scale, particularly in the Western world. The far-reaching implications of Islamophobia have affected Muslim clinicians with challenges in their patient-clinician relations. We attempt to highlight some of these challenges and the particularities in the psychiatric setting through clinical cases. We offer recommendations and advice to Muslim psychiatrists and their colleagues on how to approach and address these challenges.