Climate change represents a well-known global challenge to the preservation of the built environment, anthropogenic and natural ecosystems, and in particular, historical heritage, especially in areas of high incidence in sudden and increasingly violent meteoclimatic phenomena. In this context, the discipline of conservation that calls for creative reuse may emerge as a key strategy in the fight against climate change. From this perspective, conservation leaves behind the more common approach of spot interventions and embracing a holistic approach capable of providing a systemic view of the context. Thus, in the case of regeneration, a shift from the canonical point of view of recovery as a function of the memory conveyed to posterity may occur as well as the mere exercise of re-functionalisation based on a reduced set of information. More and more, historical heritage is being associated with the concept of sustainability (Boarin, P., Resilient Communities and the Peccioli Charter. Springer, Cham, 2022) and identified as a valuable resource, not only a legacy to be preserved (ICOMOS in The future of our pasts: Engaging cultural heritage in climate action 2019). This paper aspires to define how built heritage, and its preservation can be identified as an integrated mitigation and adaptation strategy which can be effective in countering the effects of climate change according to risk management in contexts of fragility.