This paper analyzes and describes globalization, business, and achieving business goals in business and entrepreneurship by focusing more on the case of female business leadership. The research questions are “what rate of business leadership is there for women and men?”, “is business leadership linked to globalization?”, and “what conditions are there to reach business objectives through business leadership?” The results show that understanding the relationship between globalization and business leadership to achieve business goals is highly important for corporate strategies under the different requirements and conditions. The success of organizational leadership lies precisely in the success of the leader and the leader’s success will depend on her ability to build an environment of respect, trust, and motivation. In conclusion, in the context of globalization there are symbols that represent both society and business such as integration and convenient communication, the free circulation of goods, expansion of human rights, and social or business leadership. The percentage of female leaders in business is still low compared to men that has the high majority. The example of Latin American showed that in 2021 could reach 55% of female leaders in business activities and entrepreneurship according to the available data compared to a low percent in Europe and worldwide due to factors that probably business policies hide for business.