This study proposes an integrated methodology for evaluating the boundary layer thickness on building façades under airflow impingement. The objective is to find spatial characteristics of boundary layer formation on building surfaces for different types of urban development, considering microclimatic parameters. The scientific novelty lies in the development methodology, which combines theoretical analysis, experimental measurements, and CFD simulations, ensuring higher accuracy in predicting building thermal performance and improving energy-efficient heating strategies. For the first time, it is shown that the coordinate, where the transition from gradient to non-gradient flow regimes happened, depends on both airflow velocity and temperature, allowing precise prediction of this critical phenomenon. Furthermore, unlike existing models, the proposed approach considers wind flow angle and velocity, which significantly impact local boundary layer characteristics and heat loss distribution. The practical significance of the study is the ability to accurately forecast façade heat losses, assess wind loads, and optimize energy efficiency. The obtained analytical dependencies and approximation functions for boundary layer thickness distribution can be applied in urban planning and architectural design to ensure microclimatic comfort and durability of building envelopes.