The analysis centers on the hybrid work environment’s influence on the physical, social, and psychological well-being of employees. Drawing on survey data, the author explores challenges and effective actions for improving well-being within hybrid structures, including fostering organizational connectedness and minimizing isolation as well as maintaining work–life balance. The chapter also guides HR practitioners and managers, emphasizing the importance of taking care of the well-being of employees. The results are the starting point for further research in this area.