Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in communication, social interaction, and repetitive behaviors. Nutritional interventions have gained attention for managing ASD symptoms, particularly gluten-free and casein-free (GFCF) diets. Millets, a group of highly nutritious, gluten-free grains, are emerging as a promising dietary option for individuals with ASD. Rich in essential nutrients such as fiber, protein, vitamins, and minerals, millets contribute to gut health, neurotransmitter function, and overall brain development. This chapter explores the potential role of millets in addressing ASD-related nutritional deficiencies, their impact on gut microbiota, and their benefits in reducing inflammation and oxidative stress, which are commonly associated with autism. The chapter also highlights clinical studies, practical dietary recommendations, and future research directions in integrating millets into autism-friendly nutrition plans.